http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/365 2026-04-05T23:53:42Z http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1751 Title: The Inflammatory Response in Metabolic Syndrome. Authors: Martínez Pérez, Luz Andrea; González Sánchez, Grecia Denisse; Martínez Esquivias, Fernando; Becerra Ruiz, Julieta Saraí; Guzmán Flores, Juan Manuel Abstract: Metabolic syndrome (MS) encompasses a cluster of metabolic disorders that significantly increase the risk of developing cardiovascular diseases and type 2 diabetes mellitus. While the precise etiology of MS remains unclear, it is widely recognized as a multifactorial condition influenced by environmental, lifestyle, and genetic factors. Inflammation, a fundamental physiological response designed to maintain homeostasis, plays a central role in MS. When the body detects foreign substances or cellular stress, the immune system is activated, synthesizing signaling molecules, such as cytokines and chemokines. However, prolonged or dysregulated immune activation can result in chronic low-grade inflammation, a hallmark of MS. This persistent inflammatory state contributes to the pathophysiology of MS by promoting insulin resistance, endothelial dysfunction, and adipose tissue remodeling. The diagnostic criteria for MS, including central obesity, dyslipidemia, hyperglycemia, and hypertension, are all associated with inflammatory processes mediated by the activation of both innate and adaptive immune systems. This review explores the intricate relationship between each diagnostic criterion of MS and the inflammatory response. By delving into the immunological mechanisms underpinning MS, we aim to understand how inflammation links metabolic dysregulation to disease progression comprehensively. This knowledge could pave the way for targeted therapeutic interventions and lifestyle modifications to mitigate the global burden of MS. Description: Artículo 2025-06-01T00:00:00Z http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1589 Title: Concomitant use of allopathic medicine and herbal products for weightloss among people with overweight or obesity from Central Mexico Authors: Alonso Castro, Angel Josabad; Ruiz Padilla, Alan Joel; Carranza, Eleazar; Ramírez Morales, Marco Antonio; Isiordia Espinoza, Mario Alberto; Ibarra Reynoso, Lorena del Rocío; Domínguez, Fabiola; Ruiz Noa, Yeniley; Brennan Bourdon, Lorena Michele; Blanco Sandate, Christian; Morales Hernández, Gerardo Abstract: Abstract: This study evaluated the prevalence of concomitant use of herbal products for weight loss (HPWL) and allopathic medicine. Factors associated with the prevalence, adverse reactions, and the alteration of medication adherence with the concomitant use of HPWL alone and in combination with allopathic medicine, were assessed. The study was descriptive and cross-sectional using a questionnaire conducted among people with overweight or obesity (n=662) from five cities of Central Mexico. Adherence to medications was measured using the Morisky Medication Adherence Scale. The prevalence of adverse reactions induced by the concomitant use of HPWL, and allopathic medicine was 25.3%. The use of HPWL affected medication adherence by 68%. There is a high prevalence (45.2%) of concomitant use of HPWL and allopathic medicine in people with overweight or obesity in Central Mexico. The concomitant use of HPWL and allopathic medicine induces adverse reactions, mainly gastrointestinal, and thus, medication adherence is affected. Resumen: Este estudio evaluó la prevalencia del uso concomitante de productos a base de hierbas para bajar de peso (HPWL) y medicina alopática. Se evaluaron los factores asociados con la prevalencia, las reacciones adversas y la alteración de la adherencia a la medicación con el uso concomitante de HPWL solo y en combinación con medicina alopática. El estudio fue descriptivo y transversal mediante un cuestionario realizado entre personas con sobrepeso u obesidad (n = 662) de cinco ciudades del centro de México. La adherencia a los medicamentos se midió mediante la Escala de adherencia a la medicación de Morisky. La prevalencia de reacciones adversas inducidas por el uso concomitante de HPWL y medicina alopática fue del 25,3%. El uso de HPWL afectó la adherencia a la medicación en un 68%. Existe una alta prevalencia (45.2%) de uso concomitante de HPWL y medicina alopática en personas con sobrepeso u obesidad en el centro de México. El uso concomitante de HPWL y medicina alopática induce reacciones adversas, principalmente gastrointestinales, y por tanto, afecta la adherencia a la medicación. Description: Artículo 2023-03-01T00:00:00Z http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1514 Title: Evaluation of nutritional characteristics and bioactive compounds of soursop-yoghurt and soursop-frozen dessert Authors: Virgen Ceceña, Lucila J.; Anaya Esparza, Luis Miguel; Coria Téllez, Ana V.; García Magaña, María de Lourdes; García Galindo, Hugo S.; Yahia, Elhadi M.; Montalvo González, Efigenia Abstract: Abstract The nutritional quality, sensory attributes, polyphenols and acetogenins content in yoghurt and frozen dessert formulated with soursop pulp were investigated. The addition of soursop pulp to yoghurt and frozen dessert improved the sensory attributes and the nutritional quality of soursop dairy products resulting in a composition of 0.92 and 2.17% of dietary fiber, 11.25 and 9.84 mg/100 g of vitamin C as well as 243.02 and 490.98 mg/100 g of total polyphenols, respectively. Acetogenins were extracted from both dairy products using maceration, sonication, microwave and Soxhlet. Sonication showed to be faster and safer than the other methods for acetogenins extraction. Higher annonacin (an acetogenin) content was found in yoghurt (38 ng/g) than in frozen dessert (15 ng/g). The quantification of bioactive compounds implied the nutraceutical properties to yoghurt and ice cream when they are added with soursop pulp. The results are useful for the consumers seeking healthier foods. Description: Artículo 2019-10-01T00:00:00Z http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1178 Title: In vitro and in vivo anti-inflammatory effects of an ethanol extract from the aerial parts of Eryngium carlinae F. Delaroche (Apiaceae) Authors: Arana Argáez, Víctor Ermilo; Alonso Castro, Ángel Josabad; Yáñez Barrientos, Eunice; Euan Canto, Antonio; Torres Romero, Julio Cesar; Isiordia Espinoza, Mario Alberto; Brennan Bourdon, Lorena Michele; Juárez Vázquez, María del Carmen; González Ibarra, Alan Alexander Abstract: (https://www.sciencedirect.com/science/article/pii/S0378874120332918) Abstract: Ethnopharmacological relevance Eryngium carlinae F. Delaroche (Apiaceae) is an herb used in folk medicine as a diuretic, analgesic, and anti-inflammatory agent. Aim of the study: This work assessed the diuretic, antinociceptive, and anti- inflammatory actions of an ethanol extract from the leaves and stems of Eryngium carlinae (ECE). These ethnomedicinal properties of ECE were scientifically validated using in vitro and in vivo assays. Materials and methods The antinociceptive and diuretic actions of ECE (10–200 mg/kg p.o.) were assessed with the acetic acid-induced writhing test and by using metabolic cages to house mice, respectively. The in vitro anti-inflammatory actions of ECE (1–500 μg/ml) were evaluated using LPS-stimulated primary murine macrophages, and the in vivo anti-inflammatory actions were assessed using the TPA-induced ear edema test (2 mg/ear) and carrageenan-induced paw edema test (50–200 mg/kg p.o.). The production of inflammatory mediators was estimated using in vitro and in vivo assays. Results ECE lacked antinociceptive and diuretic effects. ECE increased the production of IL-10 in LPS-stimulated macrophages (EC50 = 37.8 pg/ml) and the carrageenan-induced paw edema test (ED50 = 82.6 mg/kg). ECE showed similar in vivo anti-inflammatory actions compared to those observed with indomethacin. Conclusion: ECE exerts in vitro and in vivo anti-inflammatory effects by increasing the release of IL-10. Description: Artículo 2021-02-01T00:00:00Z