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Title: | Sex-dependent mechanisms involved in renal tolerance to ischemia-reperfusion: Role of inflammation and histone H3 citrullination |
Authors: | Melo, Zesergio Gutiérrez Mercado, Yanet Karina García Martínez, David Portilla de Buen, Eliseo Canales Aguirre, Alejandro A. González González, Ricardo Franco Acevedo, Adriana Palomino, Julio Echavarría, Raquel |
Keywords: | ischemia-reperfusion sexual dimorphism ovarian hormones inflammation histone citrullination |
Issue Date: | Dec-2020 |
Publisher: | Elsevier |
Citation: | Melo Z., Gutierrez-Mercado Y.K., Garcia-Martínez D., Portilla-de-Buen E., Canales-Aguirre A.A., Gonzalez-Gonzalez R., Franco-Acevedo A., Palomino J., Echavarria R. (2020). Sex-dependent mechanisms involved in renal tolerance to ischemia-reperfusion: Role of inflammation and histone H3 citrullination. Transplant Immunology, Volume 63, 101331. ISSN 0966-3274. DOI: https://doi.org/10.1016/j.trim.2020.101331. |
Series/Report no.: | Transplant Immunology;Volume 63, December 2020, 101331 |
Abstract: | Abstract Ischemia-reperfusion (I/R) injury, an inevitable result of kidney transplantation, triggers early inflammatory events that affect graft viability. Evidence from human transplantation and preclinical models of I/R suggests that a female hormonal environment positively influences the ability to recover from ischemic injury. However, the mechanisms behind these effects remain mostly unexplored. Here, we studied the influence of sex on pro-inflammatory mediators involved in the pathophysiology of acute I/R injury in male, female, and female ovariectomized (OVX) Wistar rats that underwent unilateral renal ischemia for 45 min, followed by 24 h of reperfusion. We found improved renal function, reduced cytokine expression, and decreased infiltration of myeloperoxidase-positive cells in females after I/R, when compared to their male and female OVX counterparts. Remarkably, citrullination of histone H3 was exacerbated in serum and renal tubules of females after I/R. In contrast, we observed lower levels of citrullinated histone H3 in male and female OVX rats in response to I/R, mostly in neutrophil extracellular traps. Our results demonstrate that female sex promotes renal I/R tolerance by attenuating pro-inflammatory mediators involved in I/R-induced damage. |
Description: | Artículo |
URI: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1194 |
ISSN: | 0966-3274 |
Appears in Collections: | 2412 Artículos |
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