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Title: | Cysticidal effect of a pure naphthoquinone on Taenia crassiceps cysticerci |
Authors: | Aranda López, Yuli López López, Lluvia Nava Castro, Karen Elizabeth Ponce Regalado, María Dolores Becerril Villanueva, Luis Enrique Girón Pérez, Manuel Iván Del Río Araiza, Víctor Hugo Morales Montor, Jorge |
Keywords: | naphthoquinone anti-helminthic taeniasis cysticercosis taenia crassiceps drug |
Issue Date: | Nov-2021 |
Publisher: | Springer Nature |
Citation: | Aranda-López, Y., López-López, L., Castro, K.E.N. et al. Cysticidal effect of a pure naphthoquinone on Taenia crassiceps cysticerci. Parasitol Res 120, 3783–3794 (2021). https://doi.org/10.1007/s00436-021-07281-x |
Series/Report no.: | Parasitology Research;Volume 120, issue 11, November 2021 |
Abstract: | Cysticercosis is a disease caused by the metacestode of the parasite Taenia solium (T. solium). In humans, the most severe complication of the disease is neurocysticercosis. The drug of choice to treat this disease is albendazole; however, the bioavailability and efficacy of the drug are variable. Therefore, new molecules with therapeutic effects against this and other parasitic infections caused by helminths must be developed. Naphthoquinones are naphthalene-derived compounds that possess antibacterial, antifungal, antitumoral, and antiparasitic properties. The aim of this work was to evaluate the in vitro anti-helminthic effect of 2-[(3-chlorophenylamino)phenylmethyl]-3-hydroxy-1,4-naphthoquinone, isolated from a natural source and then synthesized (naphthoquinone 4a), using an experimental model of murine cysticercosis caused by Taenia crassiceps (T. crassiceps). This compound causes paralysis in the cysticerci membrane from day 3 of the in vitro treatment. Additionally, it induces changes in the shape, size, and appearance of the cysticerci and a decrease in the reproduction rate. In conclusion, naphthoquinone 4a has in vitro cysticidal activity on T. crassiceps cysticerci depending on the duration of the treatment and the concentration of the compound. Therefore, it is a promising drug candidate to be used in T. crassiceps and possibly T. solium infections. |
Description: | Artículo |
URI: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1349 |
ISSN: | 0932-0113 print 1432-1955 online |
Appears in Collections: | 3212 Artículos |
Files in This Item:
File | Description | Size | Format | |
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Cysticidal effect of a pure naphthoquinone.pdf | Documento | 2.81 MB | Adobe PDF | View/Open |
Enlace a_Cysticidal effect of a pure naphthoquinone.htm | Enlace a publicación | 48.73 kB | HTML | View/Open |
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