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Title: | Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium |
Authors: | Ponce Regalado, María Dolores Salazar Juárez, Alberto Rojas Espinosa, Oscar Contis Montes de Oca, Arturo Hurtado Alvarado, Gabriela Arce Paredes, Patricia Pérez Sánchez, Gilberto Pavón, Lenin Girón Pérez, Manuel Iván Hernández Pando, Rogelio Álvarez Sánchez, María Elizbeth Becerril Villanueva, Luis Enrique |
Keywords: | anxiolytic behavior depression-like behavior chronic infection central nervous system murine leprosy |
Issue Date: | Jun-2022 |
Publisher: | Elsevier - Science Direct |
Citation: | M.D. Ponce-Regalado, A. Salazar-Juárez, O. Rojas-Espinosa, A. Contis-Montes de Oca, G. Hurtado-Alvarado, P. Arce-Paredes, G. Pérez-Sánchez, L. Pavón, M.I. Girón-Pérez, R. Hernández-Pando, M.E. Alvarez-Sánchez, Enrique Becerril-Villanueva, Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium, Neuroscience, Volume 493, 2022, Pages 15-30, ISSN 0306-4522, https://doi.org/10.1016/j.neuroscience.2022.03.021. |
Series/Report no.: | Neuroscience;Volume 493, 2022 |
Abstract: | Abstract: Murine leprosy is a systemic infectious disease of mice caused by Mycobacterium lepraemurium (MLM) in which the central nervous system (CNS) is not infected; nevertheless, diseased animals show measurable cognitive alterations. For this reason, in this study, we explored the neurobehavioral changes in mice chronically infected with MLM. BALB/c mice were infected with MLM, and 120 days later, the alterations in mice were evaluated based on immunologic, histologic, endocrine, neurochemical, and behavioral traits. We found increases in the levels of IL-4 and IL-10 associated with high bacillary loads. We also found increase in the serum levels of corticosterone, epinephrine, and norepinephrine in the adrenal gland, suggesting neuroendocrine deregulation. Mice exhibited depression-like behavior in the tail suspension and forced swimming tests and anxiolytic behavior in the open field and elevated plus maze tests. The neurobehavioral alterations of mice were correlated with the histologic damage in the prefrontal cortex, ventral hippocampus, and amygdala, as well as with a blood–brain barrier disruption in the hippocampus. These results reveal an interrelated response of the neuroimmune-–endocrinological axis in unresolved chronic infections that result in neurocognitive deterioration. |
Description: | Artículo |
URI: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1352 |
ISSN: | 0306-4522 (Print) 1873-7544 (Electronic) 0306-4522 (Linking) |
Appears in Collections: | 3212 Artículos |
Files in This Item:
File | Description | Size | Format | |
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Development of Anxiolytic and Depression.pdf | Documento | 6.44 MB | Adobe PDF | View/Open |
Enlace a_Development of Anxiolytic and Depression.htm | Enlace a publicación | 48.71 kB | HTML | View/Open |
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