Please use this identifier to cite or link to this item: http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1352
Title: Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium
Authors: Ponce Regalado, María Dolores
Salazar Juárez, Alberto
Rojas Espinosa, Oscar
Contis Montes de Oca, Arturo
Hurtado Alvarado, Gabriela
Arce Paredes, Patricia
Pérez Sánchez, Gilberto
Pavón, Lenin
Girón Pérez, Manuel Iván
Hernández Pando, Rogelio
Álvarez Sánchez, María Elizbeth
Becerril Villanueva, Luis Enrique
Keywords: anxiolytic behavior
depression-like behavior
chronic infection
central nervous system
murine leprosy
Issue Date: Jun-2022
Publisher: Elsevier - Science Direct
Citation: M.D. Ponce-Regalado, A. Salazar-Juárez, O. Rojas-Espinosa, A. Contis-Montes de Oca, G. Hurtado-Alvarado, P. Arce-Paredes, G. Pérez-Sánchez, L. Pavón, M.I. Girón-Pérez, R. Hernández-Pando, M.E. Alvarez-Sánchez, Enrique Becerril-Villanueva, Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium, Neuroscience, Volume 493, 2022, Pages 15-30, ISSN 0306-4522, https://doi.org/10.1016/j.neuroscience.2022.03.021.
Series/Report no.: Neuroscience;Volume 493, 2022
Abstract: Abstract: Murine leprosy is a systemic infectious disease of mice caused by Mycobacterium lepraemurium (MLM) in which the central nervous system (CNS) is not infected; nevertheless, diseased animals show measurable cognitive alterations. For this reason, in this study, we explored the neurobehavioral changes in mice chronically infected with MLM. BALB/c mice were infected with MLM, and 120 days later, the alterations in mice were evaluated based on immunologic, histologic, endocrine, neurochemical, and behavioral traits. We found increases in the levels of IL-4 and IL-10 associated with high bacillary loads. We also found increase in the serum levels of corticosterone, epinephrine, and norepinephrine in the adrenal gland, suggesting neuroendocrine deregulation. Mice exhibited depression-like behavior in the tail suspension and forced swimming tests and anxiolytic behavior in the open field and elevated plus maze tests. The neurobehavioral alterations of mice were correlated with the histologic damage in the prefrontal cortex, ventral hippocampus, and amygdala, as well as with a blood–brain barrier disruption in the hippocampus. These results reveal an interrelated response of the neuroimmune-–endocrinological axis in unresolved chronic infections that result in neurocognitive deterioration.
Description: Artículo
URI: http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1352
ISSN: 0306-4522 (Print)
1873-7544 (Electronic)
0306-4522 (Linking)
Appears in Collections:3212 Artículos

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