Please use this identifier to cite or link to this item: http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1352
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dc.contributor.authorPonce Regalado, María Dolores-
dc.contributor.authorSalazar Juárez, Alberto-
dc.contributor.authorRojas Espinosa, Oscar-
dc.contributor.authorContis Montes de Oca, Arturo-
dc.contributor.authorHurtado Alvarado, Gabriela-
dc.contributor.authorArce Paredes, Patricia-
dc.contributor.authorPérez Sánchez, Gilberto-
dc.contributor.authorPavón, Lenin-
dc.contributor.authorGirón Pérez, Manuel Iván-
dc.contributor.authorHernández Pando, Rogelio-
dc.contributor.authorÁlvarez Sánchez, María Elizbeth-
dc.contributor.authorBecerril Villanueva, Luis Enrique-
dc.date.accessioned2022-06-22T18:22:34Z-
dc.date.available2022-06-22T18:22:34Z-
dc.date.issued2022-06-
dc.identifier.citationM.D. Ponce-Regalado, A. Salazar-Juárez, O. Rojas-Espinosa, A. Contis-Montes de Oca, G. Hurtado-Alvarado, P. Arce-Paredes, G. Pérez-Sánchez, L. Pavón, M.I. Girón-Pérez, R. Hernández-Pando, M.E. Alvarez-Sánchez, Enrique Becerril-Villanueva, Development of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemurium, Neuroscience, Volume 493, 2022, Pages 15-30, ISSN 0306-4522, https://doi.org/10.1016/j.neuroscience.2022.03.021.es, en
dc.identifier.issn0306-4522 (Print)-
dc.identifier.issn1873-7544 (Electronic)-
dc.identifier.issn0306-4522 (Linking)-
dc.identifier.otherhttps://doi.org/10.1016/j.neuroscience.2022.03.021-
dc.identifier.urihttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1352-
dc.descriptionArtículoes, en
dc.description.abstractAbstract: Murine leprosy is a systemic infectious disease of mice caused by Mycobacterium lepraemurium (MLM) in which the central nervous system (CNS) is not infected; nevertheless, diseased animals show measurable cognitive alterations. For this reason, in this study, we explored the neurobehavioral changes in mice chronically infected with MLM. BALB/c mice were infected with MLM, and 120 days later, the alterations in mice were evaluated based on immunologic, histologic, endocrine, neurochemical, and behavioral traits. We found increases in the levels of IL-4 and IL-10 associated with high bacillary loads. We also found increase in the serum levels of corticosterone, epinephrine, and norepinephrine in the adrenal gland, suggesting neuroendocrine deregulation. Mice exhibited depression-like behavior in the tail suspension and forced swimming tests and anxiolytic behavior in the open field and elevated plus maze tests. The neurobehavioral alterations of mice were correlated with the histologic damage in the prefrontal cortex, ventral hippocampus, and amygdala, as well as with a blood–brain barrier disruption in the hippocampus. These results reveal an interrelated response of the neuroimmune-–endocrinological axis in unresolved chronic infections that result in neurocognitive deterioration.es, en
dc.language.isoenes, en
dc.publisherElsevier - Science Directes, en
dc.relation.ispartofseriesNeuroscience;Volume 493, 2022-
dc.subjectanxiolytic behaviores, en
dc.subjectdepression-like behaviores, en
dc.subjectchronic infectiones, en
dc.subjectcentral nervous systemes, en
dc.subjectmurine leprosyes, en
dc.titleDevelopment of Anxiolytic and Depression-like Behavior in Mice Infected with Mycobacterium lepraemuriumes, en
dc.typeArticlees, en
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