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http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1353
Title: | Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway |
Authors: | Camacho Pérez, Milton Rafael Covantes Rosales, Carlos Eduardo Toledo Ibarra, Gladys Alejandra Mercado Salgado, Ulises Ponce Regalado, María Dolores Díaz Resendiz, Karina Janice Guadalupe Girón Pérez, Manuel Iván |
Keywords: | cholinergic system inflammation organophosphorus pesticides |
Issue Date: | Apr-2022 |
Publisher: | MDPI |
Citation: | Camacho-Pérez MR, Covantes-Rosales CE, Toledo-Ibarra GA, Mercado-Salgado U, Ponce-Regalado MD, Díaz-Resendiz KJG, Girón-Pérez MI. Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway. Int J Mol Sci. 2022 Apr 20;23(9):4523. doi: 10.3390/ijms23094523. PMID: 35562914; PMCID: PMC9104626. |
Series/Report no.: | International journal of molecular sciences.;2022 Apr 20;23(9):4523 |
Abstract: | Organophosphorus pesticides (OPs) are widespread insecticides used for pest control in agricultural activities and the control of the vectors of human and animal diseases. However, OPs' neurotoxic mechanism involves cholinergic components, which, beyond being involved in the transmission of neuronal signals, also influence the activity of cytokines and other pro-inflammatory molecules; thus, acute and chronic exposure to OPs may be related to the development of chronic degenerative pathologies and other inflammatory diseases. The present article reviews and discusses the experimental evidence linking inflammatory process with OP-induced cholinergic dysregulation, emphasizing the molecular mechanisms related to the role of cytokines and cellular alterations in humans and other animal models, and possible therapeutic targets to inhibit inflammation. |
Description: | Artículo |
URI: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1353 |
ISSN: | 1422-0067 (Electronic) 1422-0067 (Linking) |
Appears in Collections: | 3212 Artículos |
Files in This Item:
File | Description | Size | Format | |
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Organophosphorus Pesticides as Modulating Substances.pdf | Documento | 4.48 MB | Adobe PDF | View/Open |
Enlace a_Organophosphorus Pesticides as Modulating Substances.htm | Enlace a publicación | 51.48 kB | HTML | View/Open |
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