Please use this identifier to cite or link to this item: http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1531
Title: Effect of Low Doses of Dexamethasone on Experimental Pulmonary Tuberculosis
Authors: Lara Espinoza, Jacqueline V.
Arce Aceves, María Fernanda
Barrios Payán, Jorge
Mata Espinosa, Dulce
Lozano Ordaz, Vasti
Becerril Villanueva, Luis Enrique
Ponce Regalado, María Dolores
Hernández Pando, Rogelio
Keywords: apoptosis
dexamethasone
glucocorticoids
lung
tuberculosis
Issue Date: Jun-2023
Publisher: NIH National Library of Medicine
Citation: Lara-Espinosa JV, Arce-Aceves MF, Barrios-Payán J, Mata-Espinosa D, Lozano-Ordaz V, Becerril-Villanueva E, Ponce-Regalado MD, Hernández-Pando R. Effect of Low Doses of Dexamethasone on Experimental Pulmonary Tuberculosis. Microorganisms. 2023 Jun 10;11(6):1554. doi: 10.3390/microorganisms11061554. PMID: 37375056; PMCID: PMC10305529.
Series/Report no.: Microorganisms;2023 Jun 10;11(6):1554
Abstract: Tuberculosis (TB) is the deadliest disease caused by a bacterial agent. Glucocorticoids (GCs) have a typical anti-inflammatory effect, but recently it has been shown that they can present proinflammatory activity, mainly by increasing molecules from innate immunity. In the current study, we evaluated the effect of low doses of dexamethasone on Mycobacterium tuberculosis in vivo and in vitro. We used an established mice model of progressing tuberculosis (TB) in the in vivo studies. Intratracheal or intranasal dexamethasone therapy administered with conventional antibiotics in the late stage of the disease decreased the lung bacilli load and lung pneumonia, and increased the survival of the animals. Finally, the treatment decreased the inflammatory response in the SNC and, therefore, sickness behavior and neurological abnormalities in the infected animals. In the in vitro experiments, we used a cell line of murine alveolar macrophages infected with Mtb. Low-dose dexamethasone treatment increased the clearance capacity of Mtb by MHS macrophages, MIP-1α, and TLR2 expression, decreased proinflammatory and anti-inflammatory cytokines, and induced apoptosis, a molecular process that contributes to the control of the mycobacteria. In conclusion, the administration of low doses of dexamethasone represents a promising adjuvant treatment for pulmonary TB.
Description: Artículo
URI: http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1531
ISSN: 2076-2607 Online
2076-2607 Print
Appears in Collections:3212 Artículos



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