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Title: | Effect of Low Doses of Dexamethasone on Experimental Pulmonary Tuberculosis |
Authors: | Lara Espinoza, Jacqueline V. Arce Aceves, María Fernanda Barrios Payán, Jorge Mata Espinosa, Dulce Lozano Ordaz, Vasti Becerril Villanueva, Luis Enrique Ponce Regalado, María Dolores Hernández Pando, Rogelio |
Keywords: | apoptosis dexamethasone glucocorticoids lung tuberculosis |
Issue Date: | Jun-2023 |
Publisher: | NIH National Library of Medicine |
Citation: | Lara-Espinosa JV, Arce-Aceves MF, Barrios-Payán J, Mata-Espinosa D, Lozano-Ordaz V, Becerril-Villanueva E, Ponce-Regalado MD, Hernández-Pando R. Effect of Low Doses of Dexamethasone on Experimental Pulmonary Tuberculosis. Microorganisms. 2023 Jun 10;11(6):1554. doi: 10.3390/microorganisms11061554. PMID: 37375056; PMCID: PMC10305529. |
Series/Report no.: | Microorganisms;2023 Jun 10;11(6):1554 |
Abstract: | Tuberculosis (TB) is the deadliest disease caused by a bacterial agent. Glucocorticoids (GCs) have a typical anti-inflammatory effect, but recently it has been shown that they can present proinflammatory activity, mainly by increasing molecules from innate immunity. In the current study, we evaluated the effect of low doses of dexamethasone on Mycobacterium tuberculosis in vivo and in vitro. We used an established mice model of progressing tuberculosis (TB) in the in vivo studies. Intratracheal or intranasal dexamethasone therapy administered with conventional antibiotics in the late stage of the disease decreased the lung bacilli load and lung pneumonia, and increased the survival of the animals. Finally, the treatment decreased the inflammatory response in the SNC and, therefore, sickness behavior and neurological abnormalities in the infected animals. In the in vitro experiments, we used a cell line of murine alveolar macrophages infected with Mtb. Low-dose dexamethasone treatment increased the clearance capacity of Mtb by MHS macrophages, MIP-1α, and TLR2 expression, decreased proinflammatory and anti-inflammatory cytokines, and induced apoptosis, a molecular process that contributes to the control of the mycobacteria. In conclusion, the administration of low doses of dexamethasone represents a promising adjuvant treatment for pulmonary TB. |
Description: | Artículo |
URI: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1531 |
ISSN: | 2076-2607 Online 2076-2607 Print |
Appears in Collections: | 3212 Artículos |
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File | Description | Size | Format | |
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Effect of Low Doses of Dexamethasone on Experimental Pulmonary Tuberculosis.pdf | Documento | 8.93 MB | Adobe PDF | View/Open |
Enlace a_Effect of Low Doses of Dexamethasone on Experimental Pulmonary Tuberculosis.htm | Enlace a publicación | 43.11 kB | HTML | View/Open |
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