Please use this identifier to cite or link to this item: http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1707
Title: A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans
Authors: Guzmán Flores, Juan Manuel
Pérez Reyes, Ángel
Vázquez Jiménez, Sonia Isela
Isiordia Espinoza, Mario Alberto
Martínez Esquivias, Fernando
Keywords: pharmacological network
curcumin
caries
Streptococcus mutans
bioinformatics
Issue Date: Jun-2024
Publisher: MDPI
Citation: Guzmán-Flores, J.M.; Pérez-Reyes, Á.; Vázquez-Jiménez, S.I.; Isiordia-Espinoza, M.A.; Martínez-Esquivias, F. A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans. Dent. J. 2024, 12, 153. https:// doi.org/10.3390/dj12060153
Series/Report no.: Dentistry Journal;Volume 12, Issue 6 (153).
Abstract: Background: Dental caries is a dynamic, multifactorial disease that destroys teeth and can affect anyone’s quality of life because it can cause tooth loss and make chewing difficult. Dental caries involves various factors, such as Streptococcus mutans and host factors. Currently, adjuvant therapies, such as curcumin, have emerged, but how they work has not been adequately described. Therefore, this work aims to identify the molecular mechanism of curcumin in caries and Streptococcus mutans. Methods: We obtained differentially expressed genes from a GEO dataset, and curcumin targets were obtained from other databases. The common targets were analyzed according to gene ontology enrichment, key genes were obtained, and binding to curcumin was verified by molecular docking. Results: Our analysis showed that curcumin presents 134 therapeutic targets in caries. According to the gene ontology analysis, these targets are mainly involved in apoptosis and inflammation. There are seven key proteins involved in the action of curcumin on caries: MAPK1, BCL2, KRAS, CXCL8, TGFB1, MMP9, and IL1B, all of which spontaneously bind curcumin. In addition, curcumin affects metabolic pathways related to lipid, purine, and pyrimidine metabolism in Streptococcus mutans. Conclusions: Curcumin affects both host carious processes and Streptococcus mutans.
Description: Artículo
URI: http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1707
ISSN: 2304-6767
Appears in Collections:3209 Artículos



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