Please use this identifier to cite or link to this item:
http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/359
Title: | MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer |
Authors: | Muñiz Mendoza, Rodolfo Ayala Madrigal, María de la Luz Partida Pérez, Miriam Peregrina Sandoval, Jorge Leal Ugarte, Evelia Macías Gómez, Nelly Peralta Leal, Valeria Meza Espinoza, Juan Pablo Moreno Ortiz, José Miguel Ramírez Ramírez, Ruth Suárez Villanueva, Alexis Sayuri Gutiérrez Angulo, Melva |
Keywords: | MLH1 gene XRCC1 gene colorectal cancer mexican population |
Issue Date: | Jun-2012 |
Publisher: | Fundação de Pesquisas Científicas de Ribeirão Preto. Brasil. |
Citation: | Muñiz-Mendoza, R., Ayala-Madrigal, M. L., Partida-Pérez, M., Peregrina-Sandoval, J., Leal-Ugarte, E., Macías-Gómez, N., … Gutiérrez-Angulo, M. (2012). MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer. Genetics and Molecular Research, 11(3), 2315–2320. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/22843073 |
Series/Report no.: | Genetics and Molecular Research;11 (3): 2315 - 2320 |
Abstract: | DNA repair proteins maintain DNA integrity; polymorphisms in genes coding for these proteins can increase susceptibility to colorectal cancer (CRC) development. We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients. Genomic DNA samples were obtained from peripheral blood of 108 individuals with CRC (study group) at diagnosis and 120 blood donors (control group) from Western Mexico; both groups were mestizos. The polymorphisms were detected by PCR-RFLP. Association was estimated by calculating the odds ratio (OR). We found that the MLH1 and XRCC1 polymorphisms were in Hardy-Weinberg equilibrium. The MLH1 655A>G polymorphism in the 655G allele was associated with a 2-fold increase risk for CRC (OR = 2.04 and 95% confidence interval (95%CI) = 1.12-3.69; P < 0.01), while the MLH1 -93G>A polymorphism allele was associated with a protective effect (OR = 0.60, 95%CI = 0.40-0.89; P = 0.01 in the -93A allele and OR = 0.32, 95%CI = 0.13-0.79; P = 0.01 in the AA genotype). The XRCC1 Arg194Trp and Arg399Gln polymorphisms did not show any significant associations. In conclusion, we found that MLH1 -93G>A and 655A>G polymorphisms are associated with CRC in Mexican patients. |
URI: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/359 |
ISSN: | 1676-5680 |
Appears in Collections: | 2409 Artículos |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Enlace a_MLH1 and XRCC1 polymorphisms .htm | Enlace a publicación | 30.1 kB | HTML | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.