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Title: | Secondary chromosomal changes in 34 Philadelphia-chromosome– positive chronic myelocytic leukemia patients from the Mexican West. |
Other Titles: | Short communication |
Authors: | Meza Espinoza, Juan Pablo Picos Cárdenas, Verónica Judith Gutiérrez Angulo, Melva González García, Juan Ramón |
Issue Date: | 2004 |
Publisher: | Elsevier Inc. |
Series/Report no.: | Cancer Genetics and Cytogenetics;148 (2004) 166–169 |
Abstract: | The clonal evolution in t(9;22)-positive chronic myelocytic leukemia (CML) is well established. Four major changes occur in more than 70% of patients: +8, i(17q), +19, and an extra Philadelphia chromosome. The frequencies of secondary chromosomal changes in 34 patients from the states of Jalisco, Nayarit, Michoacán, and Colima (the Mexican West) with Philadelphia-chromosome–positive CML were assessed. The most frequent abnormalities were tetraploidy (12 cases); +8, inv(3)(q21q26), and octoploidy (3 cases each); and +der(22)(2 cases). Some translocations not previously associated with CML were observed, such as t(2;7)(p12;q36), t(3;6)(q26;p25), t(3;17)(q26;p13), and t(6;17)(q21;q23∼q25). Significant differences were found for +8 with respect to population results from Japan and from southern, eastern, and western Europe; for i(17)(q10) from eastern Europe; for +19 from Japan and western Europe; and for +der(22) from Japan, southern Europe, and western Europe. Although polyploidy could result from endomitosis, there is no direct evidence that the BCR/ABL protein influences such a process; however, protein kinases such as MAPK, which are involved in endomitosis, are activated by the BCR/ABL protein, and so the BCR/ABL protein could promote endomitosis through the MAPK pathway. |
URI: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/374 |
ISSN: | 0165-4608 |
Appears in Collections: | 2409 Artículos |
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