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Title: | Isodicentric Y chromosomes and secondary microchromosomes. |
Authors: | Rivera, Horacio Ayala Madrigal, Laura Margarita Gutiérrez Angulo, Melva Vasquez, Al Ramos, AL |
Keywords: | isodicentric Y-chromosomes microchromosomes functional dicentricity centromere excision |
Issue Date: | 2003 |
Series/Report no.: | Genetic Counseling (Geneva, Switzerland);Volume: 14 Issue: 2 Pages: 227-231 |
Abstract: | We report here on two mosaic patients with both an idic(Yp) and a microchromosome. FISH with the DYZ3 alphoid repeat demonstrated that the isodicentrics effectively exhibited two alphoid clusters whereas the small markers had a Y-centromere. These data, along with 4 previous observations, indicate that such microchromosomes effectively result from functional dicentricity of isodicentric Y-chromosomes and represent the excision of one centromere plus various amounts of adjacent chromatin. Other than a real infrequency of such a concurrence or a very low proportion of the cell line(s) containing the microchromosome, the paucity of observations points to a high rate of underdiagnosis as revealed by two idic(Y) instances in which the microchromosome was detected only in samples assessed by FISH. |
URI: | http://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/417 |
ISSN: | 1015-8146 |
Appears in Collections: | 2409 Artículos |
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