Centro Universitario de los Altos

En los últimos años América Latina se convirtió en la región en desarrollo con los mayores niveles de urbanización del planeta. Esto ha llevado a la aparición de un sinnúmero de problemáticas sociales que retan las capacidades institucionales y ponen en peligro a la población, como sucede con las dinámicas de violencia de todo tipo, inseguridad, desigualdad, pobreza y demás. Adicionalmente, al problema de la concentración de la violencia se suman la falta de planeación, la desigualdad, el de...

¿Quiénes fueron realmente los antepasados de los alteños? Este libro ofrece una mirada rigurosa y reveladora sobre la composición “racial” de Los Altos de Jalisco durante los últimos treinta años del periodo colonial. A través del análisis estadístico de más de 200 mil registros parroquiales de bautismo, los autores desmontan mitos profundamente arraigados sobre la supuesta homogeneidad criolla de la región. El resultado es una radiografía precisa y plural de una sociedad diversa, con presenc...

Este libro nace de una experiencia empírica, construida a lo largo de varios años de trabajo formativo en el doctorado en Cognición y Aprendizaje de la Universidad de Guadalajara. En ese tiempo se diseñó y puso en práctica un conjunto de ejercicios pedagógicos cuyo propósito fue acompañar a estudiantes en el cultivo de habilidades clave para pensar, investigar y colaborar desde una lógica genuinamente interdisciplinaria. El sentido de este trabajo no es ofrecer un recetario, ni trasladar mec...

Objective This project aimed to evaluate the immunoexpression pattern of murine double minute 2 (MDM2) in solid ameloblastomas compared to unicystic ameloblastomas. Methods The review followed PRISMA guidelines and was registered in the PROSPERO database. PubMed, Scopus, ScienceDirect, Web of Science, and Google Scholar were comprehensively searched. Original cross-sectional studies were included. The meta-analysis was performed using STATA V15 and RevMan. Positivity rates were pooled us...

El cáncer colorrectal es una amenaza silenciosa. Diversos estudios internacionales han demostrado que llevar un estilo de vida saludable puede reducir significativamente el riesgo de desarrollarlo. La actividad física regular, la dieta rica en frutas, verduras, fibra y el control del peso son aliados fundamentales. Por otro lado, el consumo elevado de carnes rojas y procesadas, alcohol, fumar y la obesidad son factores que incrementan la probabilidad de alteraciones genómicas y desarrollo de ...

Background & Aims In Latin America, genetic testing for Lynch syndrome (LS) has been partially implemented. Traditionally, LS diagnosis relied on the Amsterdam criteria and Bethesda guidelines, collectively known as traditional screening (TS). However, TS may miss up to 68% of LS cases. To improve detection rates, universal tumor screening (UTS) has been introduced. UTS involves screening all newly diagnosed patients with colorectal cancer for molecular markers to more effectively identify L...

Background/Objectives: The purpose of the current study was to compare the methylation of five regions of the CpG island of MLH1 with the presence of microsatellite instability (MSI) in colorectal cancer (CRC) patients. Methods: The study analyzed 138 CRC tumor samples. DNA extraction was performed, followed by bisulfite conversion. MLH1 gene methylation was assessed by methylation-specific PCR (MS-PCR), and the resulting fragments were analyzed using polyacrylamide gels. MSI was evaluated us...

Saliva is a biofluid secreted mainly by the major and minor salivary glands, which contains a wide variety of biomolecules with diagnostic value. Its molecular abundance, noninvasive collection, molecular richness, and link to systemic conditions have established it as an attractive tool compared with blood or tissue biopsies. The present narrative review aims to integrate up-to-date knowledge about the biology of the salivary glands, the mechanisms of secretion, and the molecular constitutio...

Introduction: Gingivitis is the initial manifestation of periodontal disease, characterized by bacteria and inflammatory mediators, such as IL-32. This study aimed to determine whether the rs45499297 genetic variant of the IL32 gene and its serum and salivary levels are associated with gingivitis. In addition, we investigated whether transcription factors bind differentially in the presence of this genetic variant. Methods: The study was conducted with 147 subjects. The rs45499297 variant ...

Periodontitis and viral liver infections, particularly hepatitis B virus (HBV) and hepatitis C virus (HCV), are chronic inflammatory conditions with a high prevalence worldwide. Recent evidence establishes a possible bidirectional relationship between the two, based on shared immunological, microbial, and inflammatory mechanisms. The objective of this study was to analyze and synthesize the scientific literature on the interactions between viral hepatitis and periodontal health. Through a str...

Background Activation of the IL-23/IL-17 cytokine axis could trigger peri-implant bone loss. The aim of this review was to analyze whether in people with peri-implantitis (PI) and peri-implant mucositis (PM) the concentrations of the interleukin-23 and interleukin-17 in peri-implant crevicular fluid (PICF) are elevated compared to people with healthy dental implants (HDI). Methodology The protocol of this study was registered in OSF (ID: 10.17605/OSF.IO/U8NBQ) and followed PRISMA guideli...

bstract Oral squamous cell carcinoma (OSCC) is a malignant neoplasm with high mortality and recurrence. Its etiology is multifactorial and involves environmental factors such as smoking, alcohol, and human papilloma virus infection, as well as genetic factors such as single nucleotide polymorphisms. The fractalkine/CX3CR1 axis is key in the regulation of cell apoptosis, proliferation, migration, and invasion, which are fundamental processes in cancer development. The CX3CL1 gene, which encod...

Objective: The aim of this systematic review was to investigate, identify, and summarize the existing literature on the levels of proinflammatory cytokines and chemokines present in gingival crevicular fluid (GCF) of primary teeth restored with stainless steel crowns (SSC) versus control teeth. Materials and methods: The systematic review was registered in the Open Science Framework (ID): 10.17605/OSF.IO/39U4D. In addition, it was prepared following the guidelines of the Preferred Reportin...

Objectives This systematic review aimed to explore the role of Azurocidin (Azu) in the pathogenesis of periodontal and peri-implant disease and its potential use as an inflammatory biomarker. Materials and methods Four electronic databases were used for study identification: PubMed, Google Scholar, ScienceDirect, and Scopus from Oct 10, 1991 to Jul 15, 2024. Study selection and data extraction were performed in a blinded and independent manner. The Joanna Briggs Institute (JBI) tool was us...

Aim Molar-incisor hypomineralization (MIH) is a developmental enamel defect that presents diagnostic and treatment challenges for dental professionals. Understanding the knowledge, perception, attitude, practice, and awareness of MIH is essential for improving its management in pediatric dentistry. This systematic review evaluates the knowledge, perception, attitude, practice, and awareness of MIH among dentists and dental students. Methods A systematic search was conducted across PubMed, ...

Background Molar-incisor hypomineralization (MIH) is a qualitative defect in enamel formation with a multifactorial etiology. Studies indicate a high prevalence of MIH across the Americas, yet the prevalence in Mexico remains uncertain. Aim This study aimed to review the literature on the prevalence of MIH in the Mexican population and its associated factors. Methods Six electronic databases were searched for relevant studies: PubMed, Scopus, Dentistry & Oral Science, Science Direct,...

Background: In Mexico, tooth decay is common among children and is on the rise. A strong relationship exists between behavioral, socioeconomic, demographic, and biological factors and the severity and development of dental caries. Objective: The present study analyzed the risk factors contributing to dental caries in a Mexican pediatric population. Materials and Methods: This study employed a cross-sectional design. One hundred fifty-one children were evaluated after providing their assent an...

Metabolic syndrome (MS) encompasses a cluster of metabolic disorders that significantly increase the risk of developing cardiovascular diseases and type 2 diabetes mellitus. While the precise etiology of MS remains unclear, it is widely recognized as a multifactorial condition influenced by environmental, lifestyle, and genetic factors. Inflammation, a fundamental physiological response designed to maintain homeostasis, plays a central role in MS. When the body detects foreign substances or c...

Objective This systematic review and meta-analysis aims to assess the knowledge and awareness of oral cancer risk factors among medical and dental students. Methods This study followed the PRISMA guidelines and was registered in INPLASY (ID: 2024110035). Four databases were consulted (PubMed, Science Direct, Scopus, and Web of Science) from February 20th, 2005, to May 10th, 2024. The study selection and data extraction process was performed independently by 2 investigators. The risk of bia...